Cabolong 40mg

Product Description

Cabolong 40mg Tablet active ingredient is Cabzantinib, which belongs to a class of drugs known as tyrosine kinase inhibitors used in the treatment of Liver cancer (Hepatocellular carcinoma), Thyroid cancer, and liver cancer (Renal cell carcinoma) by killing the cancer cells.

Uses of Cabolong 40mg Tablet

Hepatocellular carcinoma (Liver cancer)

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, originating in the hepatocytes, the main type of liver cells. It usually occurs in people who have a chronic liver disease such as cirrhosis, hepatitis B or C. Symptoms include weight loss, inflamed liver, loss of appetite, stomach pain, and jaundice.

Cabolong 40 mg Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you must take it. This will depend on what you are being treated for and may change occasionally. Take it exactly as advised by the doctor. Taking it the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Renal cell carcinoma

Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults. It originates in the renal cortex, the part of the kidney where urine is first filtered. RCC accounts for about 90% of all kidney cancers. It is caused by obesity, smoking cigarettes, polycystic kidney disease, and some genetic conditions. Symptoms include blood in urine, loss of appetite, weight loss, tiredness, and fever.

Thyroid cancer

Thyroid cancer occurs when abnormal cell growth in the thyroid gland leads to the formation of a tumor. The thyroid gland, located at the base of the neck, plays a role in regulating metabolism through hormone production. Symptoms include a lump on your neck, a change in your voice, pain in your neck and throat, inflamed lymph nodes in your neck, and difficulty in swallowing.

Understanding How Cabolong 40mg Tablet Works

Cabolong 40 mg tablet is an antineoplastic medication used primarily in the treatment of advanced kidney cancer, hepatocellular carcinoma (HCC), and when Sorafenib (an anticancer medicine) is no longer working. Cabozantinib is classified as a tyrosine kinase inhibitor, which means it targets specific enzymes involved in cancer cell growth and survival.

Mechanism of Action

Cabozantinib works in multiple ways to inhibit tumor growth and spread:

Inhibition of Tyrosine Kinases:

VEGFR (Vascular Endothelial Growth Factor Receptor): Cabozantinib blocks VEGFR, a protein that promotes the formation of new blood vessels (angiogenesis) which tumors need to grow and spread.

MET (Mesenchymal-Epithelial Transition Factor): This receptor is often overexpressed in cancer cells and contributes to tumor growth, invasion, and metastasis. Inhibition of MET disrupts these processes.

AXL (Anexelekto): AXL plays a role in cancer cell survival and metastasis. By inhibiting AXL, cabozantinib reduces the ability of cancer cells to spread.

Inhibition of Tumor Angiogenesis:

By targeting and blocking VEGFR, cabozantinib effectively reduces the tumor’s blood supply. This limits the nutrients and oxygen available to the tumor, inhibiting its growth and causing cell death.

Disruption of Cancer Cell Survival Pathways:

Cabozantinib interferes with various cellular pathways that cancer cells use to survive, grow, and spread. By blocking MET and AXL, it disrupts these pathways, leading to reduced cancer cell proliferation and increased apoptosis (programmed cell death).

Monitoring and Side Effects of Cabolong 40mg

Patients on Cabolong 40 mg require regular monitoring due to potential side effects, which may include:

Serious

• Gastrointestinal Perforation: This is a serious condition where a hole forms in the wall of the stomach, intestine, or other part of the digestive tract, leading to leakage of digestive contents into the abdominal cavity. It requires immediate medical attention.
• Severe or Uncontrollable Bleeding: This can be due to a variety of causes, including trauma, bleeding disorders, or severe gastrointestinal issues. It’s a medical emergency that needs prompt treatment.
• Shortness of Breath: This can be a sign of respiratory or cardiovascular issues, such as asthma, pulmonary embolism, or heart failure. It should be evaluated by a healthcare professional.
• Nonhealing Wound: Wounds that don’t heal properly may indicate underlying conditions such as diabetes, infection, or vascular problems. It’s important to have these evaluated to determine the cause.
• Pain in the Mouth, Jaw/Teeth, Hands, Feet: Pain in these areas could be related to dental issues, arthritis, neuropathy, or other conditions. The specific nature of the pain can help narrow down the cause.

Common

• Hair Loss
• Diarrhea
• Fatigue
• Decreased Appetite
• Hand-foot syndrome (redness, swelling, and pain on the palms of the hands and/or the soles of the feet)
• Oral Mucositis (inflammation and ulcers in the mouth)

Close monitoring helps manage these side effects and adjust treatment as necessary to ensure the best possible outcome for the patient.

Related product

• Cabolong 20mg
• Cabolong 60mg

Dosage of Cabolong 40 mg

While taking Cabolong 40 mg, the physician’s instructions are carefully required. This medication is usually prescribed to be taken once a day. It is important to swallow the tablet whole and not to crush, chew, or open it. Take medicine on an empty stomach preferably at the same time daily. The correct dosage and duration of the medication will be determined by your doctor, based on factors such as your age, body weight, and the condition being treated. Do not discontinue the medication without first consulting your physician, as they will guide you on the appropriate course of action. If you have any questions or experience any side effects, contact your healthcare provider for advice.

Cabolong 40mg Safety Advice

• Pregnancy: Cabolong may harm an unborn baby. If you are pregnant or planning to become pregnant, discuss alternative treatments with your healthcare provider.
• Breastfeeding: It is not known whether cabozantinib passes into breast milk. Consult your healthcare provider about the risks of breastfeeding while taking this medication.
• Liver: Cabolong 40mg Tablet should be used with caution in patients with liver disease. A dose adjustment of Cabolong 40mg Tablet may be needed. Please consult your doctor.
• Driving: It is not known whether Cabolong 40mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
• Kidney: Cabolong 40mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Cabolong 40mg Tablet is recommended.

FAQs

Q1) How does Cabolong 40mg TABLET work on my body?

Ans: Cabolong 40 mg is an anti-cancer medicine. It works by blocking the actions of tyrosine kinases in the body that trigger cancer formation. As a result, it manages abnormal cell division within the body and slows down the growth of cancer cells in the body.

Q2) Can the use of Cabolong 40mg Tablet cause mouth ulcers?

Ans: Mouth ulcers are one of the common side effects of taking CABOLONG 40 mg Tablet. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel to the affected areas of the mouth if required. Consult your doctor if this side effect bothers you.

Q3) Is CABOLONG 40mg Tablet a chemo drug?

Ans: CABOLONG 40 mg Tablet is not a traditional chemotherapy drug but rather a targeted therapy. It contains Cabozantinib, which is classified as a tyrosine kinase inhibitor. Unlike traditional chemotherapy drugs that generally target all rapidly dividing cells, Cabozantinib specifically targets certain proteins involved in the growth and spread of cancer cells.

Additional information